BEP for testicular cancer: 3 is as good as 4 cycles – pro
The great majority of testicular cancer is cured with limited chemotherapy and the remaining cases have a high cure rate with a transplant. The BEP regimen was proven to have less toxicity and a higher cure rate and therefore, since 1984, has been standard chemotherapy. NCCN recommends 3 cycles of BEP or 4 of EP. The notes do not indicate a particularly poor prognosis disease.
Saxman SB, Finch D, Gonin R, et al. Long-term follow-up of a phase III study of three versus four cycles of bleomycin, etoposide, and cisplatin in favorable-prognosis germ-cell tumors: The Indiana University Experience. J Clin Oncol. 1998;16:702-706.
de Wit R, Roberts JT, Wilkinson PM, et al. Equivalence of three or four cycles of bleomycin, etoposide, and cisplatin chemotherapy and of a 3- or 5- day schedule in good-prognosis germ cell cancer: a randomized study of the European Organization for Research and Treatment of Cancer Genitourinary Tract Cancer Cooperative Group and the Medical Research Council. J Clin Oncol. 2001;19:1629-1640.
NCCN Testicular Cacner 2020 TEST-4