CD 34 boost -pro
A proportion of patients develop poor graft function (PGF) following an allogeneic hemopoietic stem cell transplant (HSCT). In patients with poor graft function (a) a boost of specifically CD34+-selected peripheral blood donor cells is associated with a high chance of trilineage recovery and a low risk of acute GVHD.
A. Larocca etal, Boost of CD34+-selected peripheral blood cells without further conditioning in patients with poor graft function following allogeneic stem cell transplantation. Haematologica. 2006 Jul;91(7):935-40.
Ghobadi, Armin et al. “Fresh or Cryopreserved CD34+-Selected Mobilized Peripheral Blood Stem and Progenitor Cells for the Treatment of Poor Graft Function after Allogeneic Hematopoietic Cell Transplantation.” Biology of blood and marrow transplantation: journal of the American Society for Blood and Marrow Transplantation vol. 23,7 (2017): 1072-1077. doi:10.1016/j.bbmt.2017.03.019
Mohammadi, S., Norooznezhad, A.H., Mohammadi, A.M. et al. Optimizing peripheral blood stem cells transplantation outcome through amend relapse and graft failure: a review of current literature. Exp Hematol Oncol 6, 24 (2017). https://doi.org/10.1186/s40164-017-0082-5