Neulasta can be given on the same day – pro
Even though other guidelines continue to requireNeulast to be given 24 hours after chemotherapy, NCCN now mentions the option of same-day administration. A metanalysis showed the incidence of Grade 4 neutropenia and CTX dose reduction in patients receiving same-day pegfilgrastim were equal to those undergoing standard administration. It still needs to be confirmed through controlled studies,but per NCCN, same-day administration of pegfilgrastim can be considered in the prophylaxis of CIN/FN in patients receiving myelotoxic CTX.
Reem Diri, et al, Efficacy of Same-Day Vs. Next-Day Pegfilgrastim for the Prevention of Chemotherapy-Induced (Febrile) Neutropenia (CIN/FN): A Meta-Analysis. Blood (2015) 126 (23): 4764.