Consolidation allogeneic stem cell transplantation for T-cell prolymphocytic leukemia
A recent ASCO consensus says: ” patients achieving a complete remission should be considered for consolidation therapy with an allogeneic stem cell transplant….About a third of patients may achieve long-term survival with this approach, although TRM and relapse rates remain high”. It is also supported by NCCN Prolymphocytic Leukemia 2022.
Kharfan-Dabaja MA, Kumar A, Ayala E, Hamadani M, Reimer P, Gisselbrecht C, d’Amore F, Jantunen E, Ishida T, Bazarbachi A, Foss F, Advani R, Fenske TS, Lazarus HM, Friedberg JW, Aljurf M, Sokol L, Tobinai K, Tse E, Burns LJ, Chavez JC, Reddy NM, Suzuki R, Ahmed S, Nademanee A, Mohty M, Gopal AK, Fanale MA, Pro B, Moskowitz AJ, Sureda A, Perales MA, Carpenter PA, Savani BN. Clinical Practice Recommendations on Indication and Timing of Hematopoietic Cell Transplantation in Mature T Cell and NK/T Cell Lymphomas: An International Collaborative Effort on Behalf of the Guidelines Committee of the American Society for Blood and Marrow Transplantation.
NCCN T-cell lymphomas 2022ol Blood Marrow Transplant. 2017 Nov; 23(11):1826-1838. doi: 10.1016/j.bbmt.2017.07.027. Epub 2017 Aug 7. PMID: 28797780.
Consensus criteria for diagnosis, staging, and treatment response assessment of T-cell prolymphocytic leukemia. Blood (2019) 134 (14): 1132–1143.