IGK analysis for myeloma – pro
Next-generation sequencing (NGS) of rearranged Ig genes is an effective technology for identifying pathologic clonal cells in multiple myeloma (MM) and tracking minimal residual disease. However, evidence of clinical utility of this test is lacking. A retrospective chart review by Ha et al concluded that it provides good clonality detection rates in diagnostic samples, and allows monitoring of samples in MM patients with significant prognostic value.
Mannu, Claudia et al. “Use of IGK gene rearrangement analysis for clonality assessment of lymphoid malignancies: a single center experience.” American journal of blood research vol. 1,2 (2011): 167-74.
Jihye Ha et al, IG Gene Clonality Analysis Using Next-Generation Sequencing for Improved Minimal Residual Disease Detection with Significant Prognostic Value in Multiple Myeloma Patients. The Journal of Molecular Diagnostics Volume 24, Issue 1, January 2022, Pages 48-56
NCCN Myeloma 2022