IVIG for Mast Cell Activation Disorder – pro
Not much informatin is avaialbel on IVIG for Mast Actication Dsorder. For some case it is appropriate – There is insufficient evidence to recommend the use of IVIG. IVIG should only be considered for severe cases when antihistamines, mast cell stabilizers, leukotriene
inhibitors, corticosteroids, or other therapies are ineffective or contraindicated.” This comes from Criteria for the Clinical Use of Immune Globulin Second Edition February 2022 https://www.ihe.ca/public/uploaded/Prairie%20Ig%20Final%20Guideline%2009.02.22.pdf
Akyol, Gokce Yilmaz ; Manaenko, Anatol ; Akyol, Onat ; Solaroglu, Ihsan ; Ho, Wing Mann ; Ding, Yan ; Flores, Jerry ; Zhang, John H. ; Tang, Jiping, IVIG activates FcRIIB-SHIP1-PIP3 Pathway to stabilize mast cells and suppress inflammation after ICH in mice. Scientific Reports, Volume 7, id. 15583 Pub Date: November 2017
P. Valentt et al, Drug-induced mast cell eradication: A novel approach to treat mast cell activation disorders? Allerg CLin Immun Published:April 11, 2022 DOI:https://doi.org/10.1016/j.jaci.2022.04.003