Adjuvant chemotherapy of salivary gland cancers – pro
Radiation therapy has a role in adjuvant therapy of resected salivary gland cancers, but not chemotherapy. Lenvitinib has effectiveness in metastatic disease, but not for completely resected and radiated adenoid Cystic carcinoma. NCCN does not recommend adjuvant therapy or maintenance with Lenvitinib.
Tchekmedyian V, Sherman EJ, Dunn L, Tran C, Baxi S, Katabi N, Antonescu CR, Ostrovnaya I, Haque SS, Pfister DG, Ho AL. Phase II Study of Lenvatinib in Patients With Progressive, Recurrent or Metastatic Adenoid Cystic Carcinoma. J Clin Oncol. 2019 Jun 20;37(18):1529-1537. doi: 10.1200/JCO.18.01859. Epub 2019 Apr 2. PMID: 30939095; PMCID: PMC6599407.
NCCN Head and Neck Salivary GLand Sali-3, 20223.
Venkatasai, J., Das, A., Kaliamurthi, P., Sasidharan, B., Mathew, M., Singh, A., . . . Pavamani, S. (2021). Adjuvant therapy in the management of operable salivary duct carcinoma: Correlating evidence with a retrospective review. Journal of Radiotherapy in Practice, 1-8.