There are now two studies showing the effectiveness of Afinitor with letrozole for recurrent endometrial and ovarian cancer. This represents sufficient literature support.
Pamela T. Soliman, Shannon Neville Westin, David A Iglesias, Mark F. Munsell, Brian M. Slomovitz, Karen H. Lu, and Robert L. Coleman Phase II study of everolimus, letrozole, and metformin in women with advanced/recurrent endometrial cancer.Journal of Clinical Oncology 2016 34:15_suppl, 5506-5506
Brian M. Slomovitz, Yunyun Jiang, Melinda S. Yates, Pamela T. Soliman, Taren Johnston, Maureen Nowakowski. Phase II Study of Everolimus and Letrozole in Patients With Recurrent Endometrial Carcinoma Journal of Clinical Oncology 2015 33:8, 930-936