Angioimmunoblastic lymphoma – transplantation – pro
AILD is a type of peripheral T-cell lymphoma that is clinically characterized by high fever and generalized lymphadenopathy. AILD may represent a spectrum of disease ranging from a hyperplastic but still benign immune reaction to frank malignant lymphoma. This complicates efforts to understand if stem cell transplantation helps. High-dose chemotherapy followed by autologous bone marrow transplantation represents a promising new treatment modality for patients with advanced lymphoma and may conceivably be useful in AILD. Rodríguez et al described prolonged survival for patients with angioimmunoblastic T-cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation. A series using allogeneic hematopoietic stem cell transplantation for patients with relapsed angioimmunoblastic T-cell lymphoma showed that either myeloablative or reduced-intensity allogeneic transplantation can produce long-term disease-free survival. 2013 New Zealand Gudielines says: “Consolidation with allogeneic or autologous HSCT should be considered for patients with chemo-sensitive disease in first remission or after relapse (if not given in CR1).”
Bei Xu,Peng Liu, No Survival Improvement for Patients with Angioimmunoblastic T-Cell Lymphoma over the Past Two Decades: A Population-Based Study of 1207 Cases, PLoS ONE 9(3): e92585. 2014.
Rodríguez J, Conde E, Gutiérrez A, Arranz R, Gandarillas M, Leon A, et al. Prolonged survival of patients with angioimmunoblastic T-cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation: the GELTAMO experience. Eur J Haematol. 2007 Apr. 78(4):290-6.
redbook.streamliners.co.nz/LNZ T-cell lymphoma.pdf, 2013