Antibiotic prophylaxis – pro
Antibiotic prophylaxis is recommended by the Infectious Disese Society. Fluoroquinolone prophylaxis should be considered for high-risk patients with expected durations of prolonged and profound neutropenia (ANC<100 cells/mm3for.7 days)(B-I). Levofloxacin and ciprofloxacin have been evaluated mostcomprehensively and are considered to be roughly equivalent,although levofloxacin is preferred in situations with increased risk for oral mucositis-related invasive viridans group streptococcal infection.
| Reviewer Comments | G. Freifeld et al, Clinical Practice Guideline for the Use of Antimicrobial Agents in Neutropenic Patients with Cancer: 2010 Update by the InfectiousDiseases Society of America. CID 2011:52 (15 February
Christopher R. Flowers, Jerome Seidenfeld, Eric J. Bow, Clare Karten, Charise Gleason, Douglas K. Hawley, Antimicrobial Prophylaxis and Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy: American Society of Clinical Oncology Clinical Practice Guideline. Journal of Clinical Oncology 31, no. 6 (February 2013) 794-810. |