Aplastic anemia: Transplantation – pro
Patients older than 30 years of age, do less well with allogeneic transplantation because they tolerate GVHD less well. There is some support for using fludarabine, a more immunosuppressive drug, for such patients. On the other hand, immunosuppression is not curative like allogeneic stem cell transplantation. For this reason, Bone marrow transplantation (BMT) from a matched sibling donor remains the best choice. Young patients who do not have a matched UD or a suitable CB unit and who have failed at least 1 course of IST or have rejected a previous UD or CB graft are eligible for a transplant from HLA haploidentical family donors (HAPLO). Other donor options have sme literature supprot as well.
Andrea Bacigalupo, How I treat acquired aplastic anemia. Blood (2017) 129 (11): 1428–1436.
Uptodate Treatment of aplastic anemia in adults
Authors:Timothy S Olson, MD, PhDCynthia E Dunbar, MDSection Editor:Richard A Larson, MDDeputy Editor:Alan G Rosmarin, MD
Accessed 7/22/2022
Young, Neal S. (25 October 2018). “Aplastic Anemia”. New England Journal of Medicine. 379 (17): 1643–1656.