Breast cancer surveillance in in women with Peutz-Jeghers syndrome – pro
In women with Peutz-Jeghers syndrome, the risk of breast cancer is substantially increased, being 8% and 31% at ages 40 and 60 years. Recommendatiosn for both colon and breast cancer surveillance ahve been made by Beggs et al. For breast, it is for Annual MRI/US should start at age 25-30 years, with x-ray mammography being substituted after the age of 50. (Level
of evidence: IV, Grade of recommendation: C)
A D Beggs et al, PeutzeJeghers syndrome: a systematic review and recommendations for management. Gut. 2010 Jul;59(7):975-86.