Cancer Treatment Today

Celecoxib, sold under the brand name of Celebrex by Pfizer Inc., is a non-steroidal anti-inflammatory drug which has been explored in a number of cancers both for treatment and for prevention. There is some evidence of its effectiveness for prevention in this cancer type. One particular therapeutic approach is metronomic chemotherapy in which low doses of drugs are giving continuously over a period of time. The aim of treatment is to put cacner cells to “sleep”, thus leading to long-term control of the disease  The use of low doses of methotrexate have been shown in in-vivo and in-vitro to retard new blood vessel formation in the cancer. The combination of celecoxib and methotrexate has been reported to have good efficacy without significant toxicity. The authors of another study concluded that use of metronomic chemotherapy seems promising and well tolerated in this setting and that large trials are warranted to confirm these results. Much more research must follow before this promising treatment modality comes into routine clinical use.

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