Optune’s Instructions for use state that Optune should be continued after the first progression, changing other therapies only, and only stopped after the second progression. THe clinical trials of Optune also followed this approach.
Optune Instructions for Use, 2021
Stupp R, Taillibert S, Kanner A, et al. Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma: A Randomized Clinical Trial. JAMA. 2017;318(23):23062316. doi:10.1001/jama.2017.18718