Depen vs Syprine – pro
Depen is generally accepted as first line treatment, but Syprine is also FDA indicated for Wilson’s disease. Wilson’s disease (hepatolenticular egeneration) is an autosomal inherited metabolic defect resulting in an inability to maintain a near-zero balance of copper. Excess copper accumulates possibly because the liver lacks the mechanism to excrete free copper into the bile. Hepatocytes store excess copper but when their capacity is exceeded copper is released into the blood and is taken up into extrahepatic sites. This condition is treated with a low copper diet and the use of chelating agents, eiterh Depen or Syroine, that bind copper to facilitate its excretion from the body.
The only direct comparison of Depen and Syprine at the European Association for the Study of the Liver (EASL) 46th Annual Meeting showed both to be equally effective and both to b eels effective for neurologic complications. Depen had somewhat more side effects reported.
EASL 2011, http://www.medscape.com/viewarticle/740547
Depen, Prescribing Information 2017
Syptine, Prescribing Information 2017