GeneDx breast – pro
GeneDx is a panel of genetic predispositions for breast cancer. The panel includes: TM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, EPCAM, FANCC, MLH1, MSH2, MSH6, NBN, PALB2, PMS2, PTEN, RAD51C, RAD51D, STK11, TP53, XRCC2. While there are guidelines for some of them, such as BRCA, others are more recently identified genetic alterations and it is not known how they can be used to direct preventive measures, genetic counseling of family members or treatment of identified cases.
Walsh T et al. Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing. Proc Natl Acad Sci. 2011 Nov;108(44):18032-7.
NCCN, Breast Cancer Prevention, 2015