Genetic testing for prostate cancer – pro
Guidelines for genetic counseling and genetic testing for PCa are limited and focus only on testing of BRCA1 and BRCA 2. National Comprehensive Cancer Network (NCCN) Genetic Familial High-Risk Assessment: Breast and Ovarian (Version 2.2017) guidelines, published in the Journal of the National Comprehensive Cancer Network (2017;15:9-20), address testing BRCA1 and BRCA2 for men with a personal history of PCa limited to Gleason 7 or higher with specific family history features, or metastatic prostate cancer. The NCCN guidelines do not specifically address other genes now available for testing via multigene panels, some of which are implicated in PCa predisposition.
Giri VN, Knudsen KE, Kelly WK, et al. Role of genetic testing for inherited prostate cancer risk: Philadelphia Cancer Consensus Conference 2017. J Clin Oncol. 2017
NCCN, Prostate Cancer 2019