Germline Prostate Panel – pro
NCCN Guidelines Prostate Cancer (Version 2.2021)
Regardless of age
Metastatic prostate cancer
Very high risk: T3bT4 or primary Gleason pattern 5 or >4 cores with grade group 4 or 5
High risk: T3a or grade group 4 or 5 or PSA >20 ng/ml
It appears to recommend genetic testing, and Russo et al extend this testing to germline testing,
Any other risk group with any of the following
Ashkenazi Jewish ancestry
Prostate cancer family history: brother, father, or multiple family members diagnosed with prostate cancer at <60 years old or died from prostate cancer (grade groups 25)
3 cancers on the same side of the family (especially if diagnosed at 50 years old): bile duct, breast, colorectal, endometrial, gastric, kidney, melanoma, ovarian, pancreatic, prostate (grade groups 25), small bowel, or urothelial
Russo, J., Giri, V.N. Germline testing and genetic counselling in prostate cancer. Nat Rev Urol 19, 331343 (2022).
Germline Testing for Men With Prostate Cancer: Navigating an Expanding New World of Genetic Evaluation for V.N. Girl et al, Precision Therapy and Precision Management. Journal of Clinical Oncology 37, no. 17 (June 10, 2019) 1455-1459.
NCCN Prostte Cancer 2022