Kyphoplasty and verteroplasty in myeloma – pro
Two randomized and blinded trials found no benefit in those with osteoporosis-related fractures. 1 A number of non-blinded trials suggested effectiveness, but the lack of blinding limits what can be concluded from the results and some have been criticized due to being funded by the manufacturer 3. Information available for treating pain due to collapsed verebrae secondary to pain is of similar quality. Large case series report pain palliation in as high as 82% of patients, but controlled studies are lacking. 5
1.Robinson, Y; Olerud, C (May 2012). “Vertebroplasty and kyphoplasty–a systematic review of cement augmentation techniques for osteoporotic vertebral compression fractures compared to standard medical therapy.”. Maturitas 72 (1): 429. doi:10.1016/j.maturitas.2012.02.010. PMID 22425141.
2.Patrizia TosiDiagnosis and Treatment of Bone Disease in Multiple Myeloma: Spotlight on Spinal InvolvementScientifica Volume 2013 (2013), Article ID 104546, 12 pages
3.Gangi, A; Clark, WA (August 2010). “Have recent vertebroplasty trials changed the indications for vertebroplasty?”. Cardiovascular and interventional radiology 33 (4): 67780
4. Ramos, J. A. De Las Heras, S. Sánchez et al., “Medium-term results of percutaneous vertebroplasty in multiple myeloma,” European Journal of Haematology, vol. 77, no. 1, pp. 713, 2006.
5. R. J. McDonald, A. T. Trout, L. A. Gray, A. Dispenzieri, K. R. Thielen, and D. F. Kallmes, “Vertebroplasty in multiple myeloma: outcomes in a large patient series,” The American Journal of Neuroradiology, vol. 29, no. 4, pp. 642648, 2008.