Myeloid Molecular Profile – pro
The Myeloid Molecular Profile contains 40 key genes that can aid in establishing evidence of a clonal myeloid process—an essential step in determining the diagnostic evaluation of MDS. There is no provided information that confirms MDS in this case. In addition, this is a new test that has not been prospectively studied and , while some fo the mutations in it are metnioend in the NCCN guideline on MDS (MDS-2), many included mutations are nto well studied. As a panel, this test is not medically necessary.
2. If not, what would have been a more appropriate diagnostic test?
Malcovati L, Hellström-Lindberg E, Bowen D, et al. Diagnosis and treatment of primary myelodysplastic syndromes in adults: recommendations from the European LeukemiaNet. Blood. 2013; 122:2943-2964.
Papaemmanuil E, Gerstung M, Malcovati L, et al; Chronic Myeloid Disorders working group of the International Cancer Genome Consortium. Clinical and biological implications of driver mutations in myelodysplastic syndromes. Blood. 2013;122:3616-3627.
Haferlach T, Nagata Y, Grossmann V, et al. Landscape of genetic lesions in 944 patients with myelodysplastic syndromes. Leukemia. 2013 Nov 13. doi: 10.1038/leu.2013.336 [
NCCN, MDS MDS-2, 2016