NUT Midline carcinoma – pro
Maur M, Toss A, Dominici M, et al. Impressive Response to Dose-Dense Chemotherapy in a Patient with NUT Midline Carcinoma. Am J Case Rep. 2015;16:424429.
Harada Y et al, NUT midline carcinoma mimicking a germ cell tumor: a case report.BMC Cancer. 2016 Nov 17;16(1):895.
NUT midline carcinoma is a rare genetically defined, very aggressive squamous cell epithelial cancer that usually arises in the midline of the body and is characterized by a chromosomal rearrangement in the nuclear protein in testis gene.NUT midline carcinoma is very resistant to standard chemotherapy treatments. The tumor may initially respond to therapy, and then rapid recurrence is experienced. ANy proposed treatment is essentially experimental. Zolinza is an HDAC
inhibitor and some of these cancers have a PML protein that recruits HDAC.