Ovarian suppression for pre-menopausal women with breast cancer – pro
Suppression of ovarian estrogen production reduces the recurrence of hormone-receptorpositive early breast cancer in premenopausal women, but its value when added to tamoxifen is uncertain (atomatase inhibitors by themselves cannot be used in premenopausal women). The Texas Soft study fund that However, for women who were at sufficient risk for recurrence to warrant adjuvant chemotherapy and who remained premenopausal, the addition of ovarian suppression improved disease outcomes. Further improvement was seen with the use of exemestane plus ovarian suppression.
P.A Francis et al, Adjuvant Ovarian Suppression in Premenopausal Breast Cancer. N Engl J Med 2015; 372:436-446