Total parenteral nutrition should be avoided in patients with mild and severe AP. There have been multiple randomized trials showing that total parenteral nutrition is associated with infectious and other line-related complications. This is especially so since chemotherapy is planned in this case. A recent meta-analysis describing 8 randomized controlled clinical trials involving 381 patients found a decrease in infectious complications, organ failure, and mortality in patients with severe AP who were provided enteral nutrition as compared with total parenteral nutrition.
Scott Tenner MD, MPH, FACG1, John Baillie MB, ChB, FRCP, FACG2, John DeWitt MD, FACG3 and Santhi Swaroop Vege MD, FACG4, Management of Acute Pancreatitis J Gastroenterol 2013; 108:1400–1415;
E. Siow, Enteral Versus Parenteral Nutrition for Acute Pancreatitis Crit Care Nurse August 2008 vol. 28 no. 4 19-30
Maryam Nesvaderani, Guy D Eslick and Michael R Cox, Acute pancreatitis: update on management. Med J Aust 2015; 202 (8): 420-423