PET for staging mastocytosis – pro

Guidelines recommend staging for mastocytosis to determine the extent of systemic involvement. However, thye do not recommend specific imaging modalities. FDG uptake does not appear to be a sensitive marker of mast cell activation or proliferation because no significant FDG uptake was observed in most common forms of mastocytosis

Peter Valent et al, Guidelines and diagnostic algorithm for patients with suspected systemic mastocytosis: a proposal of the Austrian competence network (AUCNM). Am J Blood Res. 2013; 3(2): 174180.

Valent P, Akin C, Escribano L, Födinger M, Hartmann K, Brockow K, Castells M, Sperr WR, Kluin-Nelemans HC, Hamdy NA, Lortholary O, Robyn J, van Doormaal J, Sotlar K, Hauswirth AW, Arock M, Hermine O, Hellmann A, Triggiani M, Niedoszytko M, Schwartz LB, Orfao A, Horny HP, Metcalfe DD. Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria. Eur J Clin Invest. 2007;37:435453.

Mariana Castells et al, Guidelines for the Diagnosis and Treatment of Cutaneous Mastocytosis in Children. Am J Clin Dermatol. 2011 Aug 1; 12(4): 259270.

Djelbani-Ahmed et al, FDG-PET/CT findings in systemic mastocytosis: a French multicentre study.
Eur J Nucl Med Mol Imaging. 2015 Dec;42(13):2013-20.

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