Reinfusion of stem cells from the same donor in graft failure – pro
Graft failure still remains an important contributor to morbidity and mortality, following allogeneic hematopoietic stem cell transplantation (allo-HSCT). It represents only 1-2% overall transplanted patients. The most obvious manifestation of graft failure is primary graft failure, where the patient never recovers from neutropenia (ANC <0.5 × 109/L), resulting in pancytopenia and an urgent need for re-transplantation. In contrast, secondary graft failure occurs because of loss of donor cells after initial engraftment. In the latter case, autologous recovery is common; however, marrow aplasia and pancytopenia may also develop. Salvage reinfusion is an appropriate intervention to save off graft failure.
Min CK1, Kim DW, Lee JW, Min WS, Kim CC. Additional stem cell therapy for graft failure after allogeneic bone marrow transplantation.Acta Haematol. 2000;104(4):185-92.
R Olsson et al, Graft failure in the modern era of allogeneic hematopoietic SCT. Bone Marrow Transplantation (2013) 48, 537–543
Peripheral Blood as a Preferable Source of Stem Cells for Salvage Transplantation in Patients with Graft Failure after Cord Blood Transplantation: A Retrospective Analysis of the Registry Data of the Japanese Society for Hematopoietic Cell Transplantation. Biology of Blood and Marrow Transplantation Volume 18, Issue 9, September 2012, Pages 1407-1414