Relapsed intracranial germinoma – pro
Relapsedintracrnial germ cell tumors have not been prospectively studied with transplantation, but a recent review recommends it. This review by Callec et al recommends stem cell transplantation and says: ” Relapsing germinomas are highly curable; irradiation appears to play a key role. Histological proof at initial diagnosis if markers are negative is crucial. Despite inferior outcomes relapsing, NGGCTs can be cured in a significant proportion of cases provided intensive treatment including HDC is applied.”
Kubota H, Umeda K, Kagehiro K, Tanaka K, Daifu T, Hamabata T, Nodomi S, Kato I, Hiramatsu H, Arakawa Y, Mizowaki T, Adachi S. High-dose chemotherapy with autologous stem cell transplantation spares re-irradiation for recurrent intracranial germinoma. Pediatr Blood Cancer. 2018 Aug; 65(8): e27104.
DeFilipp, Z., Rosand, C., Goldstein, D. et al. Comparable outcomes following two or three cycles of high-dose chemotherapy and autologous stem cell transplantation for patients with relapsed/refractory germ cell tumors. Bone Marrow Transplant 52, 132–134 (2017).
L. Callec etal Relapsing intracranial germ cell tumors warrant retreatment. European Journal of Cancer Volume 136, September 2020, Pages 186-194