Solitary Plsmacytoma – radiation pro
Radiation can be useful for isolated palms cell tumors, but combined chemo and radiation is not well supported. If the tumor is localized (like a plasmacytoma) then high dose (50Gy) radiation may control it 88 – 95%. The cure rate is especially good for isolated plasmacytomas that are not in the bone.
The use of adjuvant or prophylactic chemotherapy for SPB is controversial. Some studies have suggested no benefit with adjuvant therapy, while others have concluded that adjuvant chemotherapy prevents or delays the median time to progression to MM. NCCN does not recommend combined treatment.
Mayr NA, Wen BC, Hussey DH, et al. The role of radiation therapy in the treatment of solitary plasmacytomas. Radiother Oncol 1990; 17:293.
Tsang RW, Gospodarowicz MK, Pintilie M, et al. Solitary plasmacytoma treated with radiotherapy: impact of tumor size on outcome. Int J Radiat Oncol Biol Phys 2001; 50:113.
16.Warsame R, Gertz MA, Lacy MQ, et al. Trends and outcomes of modern staging of solitary plasmacytoma of bone. Am J Hematol 2012; 87:647.
NCCN, Multiple Myeloma/Solitary plasmacytoma Myel-2, 2017