Stem cell boost – pro
Poor graft function (PGF) is a relatively rare post-transplantation complication associated with infections, bleeding, and secondary iron overload due to increased transfusions. There are various therapeutic approaches that potentially could improve PGF, such as stimulation of the already transplanted stem cells (eg, use of growth factors , or administration of new stem cells from the same donor (eg, a second allogeneic hematopoietic stem cell transplantation [HSCT]or CD34+-selected stem cell boost. There are no large studies but small retrospectiv4e studies suggest increased survival with us of boosts.
X. Liu, M. Wu, Y. Peng, et al, Improvement in poor graft function after allogeneic hematopoietic stem cell transplantation upon administration of mesenchymal stem cells from third-party donors: a pilot prospective stud, Cell Transplant (2013)
Evgeny Klyuchnikov et al, CD34+-Selected Stem Cell Boost without Further Conditioning for Poor Graft Function after Allogeneic Stem Cell Transplantation in Patients with Hematological Malignancies Biology of Blood and Marrow Transplantation
Volume 20, Issue 3, March 2014, Pages 382386
Stem cell boost for delayed or insufficient engraftment after allogeneic stem cell transplantation
A.A. Oyekunle1, CD34+-selected stem Cytotherapy Volume 8, Issue 4, 2006, Pages 375380
Bone Marrow Transplantation (2005) 35, 683689. doi:10.1038/sj.bmt.1704872 Published online 21 February 2005