Treating hypoglobulinemia with IV gammaglobulin – pro
Diagnostic criteria for hypogammaglobulinemia by the European Society of immunodeficiency (ESID) require a substantial decrease in IgG concentration defined by at least two standard deviations below the average for the age group. The range for healthy adults is from 8 to 12 g/L The most commonly recognized clinical feature is recurrent infection. Regularly scheduled treatment with high doses of intravenous immunoglobulins (IVIG) leads to improved outcomes, including fewer hospitalizations and severe infections.
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Ohmoto, A., Fuji, S., Shultes, K.C. et al. Controversies about immunoglobulin replacement therapy in HSCT recipients with hypogammaglobulinemia. Bone Marrow Transplant 57, 874880 (2022).
M. Otani et al, Practical guidance for teh diagnosis and management of secondary hypoglobulinemia, A work report f the AAAI primary immunodeficiency and altered immune response committees. J Aler Clin Immunol 149(5), 152501560, 2022