Sclerosing mesenteritis, also called mesenteric panniculitis, is a rare non-neoplastic disease that affects the small bowel mesentery with chronic fibrosing inflammation. Although a relatively benign condition, sclerosing mesenteritis can have a prolonged debilitating course with a fatal outcome. There are few data on the natural history and therapeutic options for this condition. Tamoxifen in combination with prednisone is the most common treatment, and most patients respond. I did not find any reports of the use of Rituxan.
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