Urine based cancer tests – pro

  • Many urine-based markers have been developed for the detection and surveillance of bladder cancer. Only five (NMP22, BTA stat, BTA TRAK, ImmunoCyt/uCyt+, and UroVysion) are FDA approved. CxBladder is available through dedicated Clinical Laboratory Improvement Amendments–certified laboratories. Two studies evaluating patients’ perspectives demonstrated that a urine marker would need a sensitivity of 95% or greater to replace cystoscopy]  Although multiple markers have been approved, current guidelines do not recommend their regular use in clinical practice. Results of large randomized studies of these markers are anticipated.
    • Darling, D., Luxmanan, C., O’Sullivan, P. et al. Clinical Utility of Cxbladder for the Diagnosis of Urothelial Carcinoma. Adv Ther 2017. doi:10.1007/s12325-017-0518-7.
    • Holyoake A, O’Sullivan P, Pollock R, et al. Development of a multiplex RNA urine test for the detection and stratification of transitional cell carcinoma of the bladder. Clin Cancer Res 2008;14:742–9.
    • Kavalieris L, O’Sullivan PJ, Frampton C, et al. Performance Characteristics of a Multigene Urine Biomarker Test for Monitoring for Recurrent Urothelial Carcinoma in a Multicenter Study. J Urol 2017;197:6,1419-1426.
    • Kavalieris L, O’Sullivan PJ, Suttie JM, et al. A segregation index combining phenotypic (clinical characteristics) and genotypic (gene expression) from a urine sample to triage out patients presenting with hematuria who have a low probability of urothelial carcinoma. BMC Urol 2015;15:23.
    • Lotan Y, Hershey JR, Shariat S, et al. The development and clinical validation of a high sensitivity urine biomarker test for the determination of recurrence in urothelial carcinoma patients. American Urological Association Annual Meeting 2016; San Diego, CA, USA.
    • Lotan Y, OʼSullivan P, Raman JD, Shariat SF, Kavalieris L, Frampton C, et al. Clinical comparison of noninvasive urine tests for ruling out recurrent urothelial carcinoma. Urologic Oncology: Seminars and Original Investigations. Elsevier; 2017; 1–8.
    • Lough T, Luo Q, Luxmanan C, et al. Clinical utility of a non-invasive urine test for risk assessing patients with no obvious benign cause of hematuria: a physician-patient real world data analysis. BMC Urol 2018;18:18.
    • O’Sullivan P, Sharples K, Dalphin M, et al. A multigene urine test for the detection and stratification of bladder cancer in patients presenting with hematuria. J Urol 2012; 188:741–7.

Categories

Blog Archives