Vitamin D is NOT protective of heart disease, but should be monitored in thalassemia – pro
Vit. D deficiency has been linked to various conditions, but the evidence securely connecting it to cardiovascular risk in not decisive and recent literature questions it. The most recent evidence published in JAMA indicates that Vitamin D supplementation is not heart protective. In thalassemia, however, recommendations are to screen for Vitamin D deficiency annually, treat those low in Vitamin D and check levels twice a year in those found deficient.
Kheiri B, Abdalla A, Osman M, Ahmed S, Hassan M, Bachuwa G. Vitamin D deficiency and risk of cardiovascular diseases: a narrative review [published correction appears in Clin Hypertens. 2018 Dec 24;24:19]. Clin Hypertens. 2018;24:9. Published 2018 Jun 22.
Barbarawi M, Kheiri B, Zayed Y, et al. Vitamin D Supplementation and Cardiovascular Disease Risks in More Than 83000 Individuals in 21 Randomized Clinical Trials: A Meta-analysis. JAMA Cardiol. Published online June 19, 2019
Soliman A, De Sanctis V, Yassin M. Vitamin d status in thalassemia major: an update. Mediterr J Hematol Infect Dis. 2013;5(1):e2013057. Published 2013 Sep 2.