Cancer Treatment Today

Vitamin D has effects on several body systems, from well-established role in bone metabolism to emerging effects on the immune system. IIn the HSCT (hematopoietic stem cell transplant) setting, vitamin D deficiency has been variably associated with increased complications, including graft-versus-host disease (GvHD), with a potential impact on survival outcomes. In a review by Ros-Soto et al, the conclusion is that the evidence base about VItamin D deficiency routine screening is is mixed, but a greater understanding of the role of vitamin D in relation to immune reconstitution following HSCT is warranted, and it called for more studies..

Jose Ros-Soto et al, Vitamin D: Is It Important in Haematopoietic Stem Cell Transplantation? A Review. Bone Marrow Transplant. 2019 Jun;54(6):810-820.
Increased incidence of chronic GvHD and CMV disease in patients with vitamin D deficiency before allogeneic stem cell transplantation.
von Bahr L, Blennow O, Alm J, Björklund A, Malmberg KJ, Mougiakakos D, Le Blanc A, Oefner PJ, Labopin M, Ljungman P, Le Blanc K.
Bone Marrow Transplant. 2015 Sep;50(9):1217-23. doi: 10.1038/bmt.2015.123. Epub 2015 Jun 1.
PMID: 26030049
Vitamin D Deficiency and Survival in Children after Hematopoietic Stem Cell Transplant.
Wallace G, Jodele S, Howell J, Myers KC, Teusink A, Zhao X, Setchell K, Holtzapfel C, Lane A, Taggart C, Laskin BL, Davies SM.
Biol Blood Marrow Transplant. 2015 Sep;21(9):1627-31. doi: 10.1016/j.bbmt.2015.06.009. Epub 2015 Jun 18.
PMID: 26093045
Vitamin D deficiency is not associated with graft versus host disease after hematopoietic stem cell transplantation: A meta-analysis.
Chiengthong K, Cheungpasitporn W, Thongprayoon C, Lertjitbanjong P, Cato LD, Bathini T, Ungprasert P, Mao MA, Chokesuwattanaskul R.
J Evid Based Med. 2020 May 5. doi: 10.1111/jebm.12383. Online ahead of print.
PMID: 32369679
Benrashid M, Moyers K, Mohr M, Salvati BN.Vitamin D deficiency, autoimmunity, and graft-versus-host-disease risk: Implication for preventive therapy